up to (a time) · by (a time)

By the end of June 2006, the number of netizens in rural China had reached three million, seven hundred and forty one thousand, making up 5.1% of the total rural population.

Up to last week, I hadn't received a reply.

By the end of 2006, the number of rural netizens in China was twenty three million one hundred thousand, showing that in six months a total of fourteen million, three hundred thousand rural Chinese got online.