huge; immense; enormous; gigantic

The company suffered big losses.

China is a huge country.

Commentators have variously described the sound of vuvuzelas as "annoying" and "satanic" and compared it with "a stampede of noisy elephants", "a deafening swarm of locusts", "a goat on the way to slaughter", "a giant hive full of very angry bees", and "a duck on speed".

The progress of science has brought about great change in our lives.

Furthermore, I still don't think this a huge cultural difference.